Steve Carell

Gru (voice)

Steve Coogan

Silas (voice)

Benjamin Bratt

Eduardo/El Macho (voice)

Miranda Cosgrove

Margo (voice)

Kristen Wiig

Lucy (voice)

Moisés Arias

Antonio (voice)

Russell Brand

Dr. Nefario (voice)

Ken Jeong

Floyd (voice)

Kristen Schaal

Shannon (voice)

Elsie Fisher

Agnes (voice)

Pierre Coffin

Kevin / Bob / Stuart / Additional Minions / Evil Minions (voice)

Director

Chris Renaud

Additional Minions / Evil Minions / Italian Waiter (voice)

Director

Dana Gaier

Edith (voice)

Nickolai Stoilov

Arctic Lab Guards (voice)

Nasim Pedrad

Jillian (voice)